A new microcapsule generation technique is presented. The microcapsule system has been built based on conventional flow cytometry. The results show that the current system can control the jet diameters of each component solution comprising a compound jet, in addition to the resultant microcapsule diameter, using the pressure balance between adjacent fluids in the hydrodynamic focusing region. It has been also shown that the synchronized breakup of the compound jet is critical for the reservoir-type morphology of the microcapsules.
Volume Subject Area:
Fluids Engineering
1.
Yeo
Y.
Basaran
O. A.
Park
K.
2003
, “A new process for making reservoir-type microcapsules using ink-jet technology and interfacial phase separation
,” Journal of Controlled Release
, 93
(2)
, pp. 161
–173
.2.
Yeo
Y.
Park
K.
2004
, “A new microencapsulation method using an ultrasonic atomizer based on interfacial solvent exchange
,” Journal of Controlled Release
, 100
(3)
, pp. 379
–388
.3.
Berkland
C.
2004
, “Uniform double-walled polymer microspheres of controllable shell thickness
. Journal of Controlled Release
,” 96
, pp. 101
–111
.4.
Ganan-Calvo
A. M.
1997
, “On the theory of electrohydrodynamically driven capillary jets
. Journal of Fluid Mechanics
,” 335
, pp. 165
–188
.5.
Ganan-Calvo
A. M.
Davila
J.
Barrero
A.
1997
, “Current and droplet size in the electrospraying of liquids. Scailing laws
,” Journal of Aerosol Science
, 28
(2)
, pp. 249
–275
.6.
Loscertales
I. G.
2002
, “Micro/nano encapsutation via electrified coaxial liquid jets
,” Science
, 295
(5560)
, pp. 1695
–1698
.7.
Freitas
S.
Merkle
H. P.
Gander
B.
2004
, “Ultrasonic atomisation into reduced pressure atmosphere-envisaging aseptic spray-drying for microencapsulation
,” Journal of Controlled Release
, 95
(2)
, pp. 185
–195
.8.
Liu
R.
2005
, “Preparation of uniform-sized PLA microcapsules by combining Shirasu Porous Glass membrane emulsification technique and multiple emulsion-solvent evaporation method
,” Journal of Controlled Release
, 103
(1)
, pp. 31
–43
.9.
Ganan-Calvo
A. M.
1998
, “Generation of steady liquid microthreads and micron-sized monodisperse sprays in gas streams
,” Physical Review Letters
, 80
(2)
, pp. 285
–288
.10.
Utada
A. S.
2005
, “Monodisperse double emulsions generated from a microcapillary device
,” Science
, 308
(5721)
, pp. 537
–541
.11.
Hildebrand
G. E.
Tack
J. W.
2000
, “Microencapsulation of peptides and proteins
,” International Journal of Pharmaceutics
, 196
(2)
, pp. 173
–176
.12.
Reithmeier
H.
Herrmann
J.
Gopferich
A.
2001
, “Development and characterization of lipid microparticles as a drug carrier for somatostatin
. International Journal of Pharmaceutics
,” 218
(1–2)
, pp. 133
–143
.13.
Freitas
S.
Merkle
H. P.
Gander
B.
2005
, “Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology
,” Journal of Controlled Release
, 102
(2)
, pp. 313
–332
.14.
Rayleigh
L.
1879
, “On the instability of Jets
,” Proceedings of the London Mathematical Society
, 10
, pp. 4
–13
.15.
Hertz
C. H.
Hermanrud
B.
1983
, “A Liquid Compound Jet
,” Journal of Fluid Mechanics
, 131
(JUN), p. 271
–287
.16.
Johns, L.E. and R. Narayanan, Interfacial Instability. 2002, New York: Springer-Verlag New York, Inc.
17.
Rao
N. V. R.
Baird
M. H. I.
1983
, “A Simple Technique for the Measurement of Surface and Interfacial-Tension
,” Journal of Physics E-Scientific Instruments
, 16
(12)
, pp. 1164
–1166
.18.
Eggers
J.
1997
, “Nonlinear dynamics and breakup of free-surface flows
,” Reviews of Modern Physics
, 69
(3)
, pp. 865
–929
.19.
Craster
R. V.
Matar
O. K.
Papageorgiou
D. T.
2002
, “Pinchoff and satellite formation in surfactant covered viscous threads
,” Physics of Fluids
, 14
(4)
, pp. 1364
–1376
.
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