A custom computer-controlled rapid prototyping system was designed and developed in this research. This system for bio-manufacturing of polymer scaffolds included 3D motion control components, a nozzle, a pressure controller, and a temperature-controlled reservoir containing a biomaterial. Heating elements built into the reservoir melted the biomaterial. The pressure line attached to the reservoir provided a controllable force that extruded the polymer biomaterial through the nozzle and deposited the polymer biomaterial onto a platform to fabricate scaffolds. A low pressure (830 KPa) system was designed and fabricated to accommodate different temperatures, motion speeds, and viscosities of polymer biomaterials. The reservoir with the nozzle was mounted to servo motor-controlled linear x-y motion devices along with a third servo motor-controlled device that controlled the z-position of the platform. Poly(ε-caprolactone) [PCL] was used to fabricate scaffolds with designed structure that were used in cell and tissue regeneration studies. 3D computer-aided design (CAD) with Pro-Engineer and computational finite element analysis (FEA) programs with MSC_Patran and MSC_Marc were used to model scaffold designs with appropriate architecture and material selection. The CAD models were used in FEA to develop new methods for determining mechanical properties of tissue scaffolds of desired structure and geometry. FEA models were validated by mechanical testing and other published results. Technology developed in this research has potential for the advancement of bio-manufacturing, and design optimization of scaffolds for tissue engineering.
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ASME 2005 International Mechanical Engineering Congress and Exposition
November 5–11, 2005
Orlando, Florida, USA
Conference Sponsors:
- Manufacturing Engineering Division and Materials Handling Division
ISBN:
0-7918-4223-1
PROCEEDINGS PAPER
Computer-Aided Design, Manufacturing, and Modeling of Polymer Scaffolds for Tissue Engineering Available to Purchase
James J.-S. Stone,
James J.-S. Stone
North Dakota State University
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Andrew R. Thoreson,
Andrew R. Thoreson
North Dakota State University
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Kurt L. Langner,
Kurt L. Langner
North Dakota State University
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Jay M. Norton,
Jay M. Norton
North Dakota State University
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Daniel J. Stone,
Daniel J. Stone
North Dakota State University
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Francis W. Wang,
Francis W. Wang
National Institute of Standards and Technology
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Shawn W. O’Driscoll,
Shawn W. O’Driscoll
Mayo Clinic School of Medicine
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Kai-Nan An
Kai-Nan An
Mayo Clinic School of Medicine
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James J.-S. Stone
North Dakota State University
Andrew R. Thoreson
North Dakota State University
Kurt L. Langner
North Dakota State University
Jay M. Norton
North Dakota State University
Daniel J. Stone
North Dakota State University
Francis W. Wang
National Institute of Standards and Technology
Shawn W. O’Driscoll
Mayo Clinic School of Medicine
Kai-Nan An
Mayo Clinic School of Medicine
Paper No:
IMECE2005-81621, pp. 169-174; 6 pages
Published Online:
February 5, 2008
Citation
Stone, JJ, Thoreson, AR, Langner, KL, Norton, JM, Stone, DJ, Wang, FW, O’Driscoll, SW, & An, K. "Computer-Aided Design, Manufacturing, and Modeling of Polymer Scaffolds for Tissue Engineering." Proceedings of the ASME 2005 International Mechanical Engineering Congress and Exposition. Manufacturing Engineering and Materials Handling, Parts A and B. Orlando, Florida, USA. November 5–11, 2005. pp. 169-174. ASME. https://doi.org/10.1115/IMECE2005-81621
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