For the establishment of the design methodologies of micro fluidic chips, the essential analysis of the flow behavior on the micro-meter scale and surface interactions on the nano-scale has been investigated. The understanding of bio-fluid flow behavior in the micro-systems includes both the basic fluid dynamic problems and driving forces from the fields of application. Attention has been focused on the clarification of the surface effects on the solution of bio-molecular flow at micro-scale dimensions. Investigations of pressure drop measurements in bio-molecular flow together with measurements of biomolecular absorption and the lateral forces on various surfaces were carried out on both micro and nano scale. The results demonstrated a clear correlation between flow drag and bio molecular interaction with the surface. The validity is demonstrated of the evaluation method suggested in this paper.

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