This paper studies the effect of temperature in the cerebral oxygen absorption and delivery using a compartmental model of oxygen transport which introduces the temperature dependence of factors such as the cerebral blood flow, the oxygen dissociation curve, and the tissue metabolic activity. The variations of the oxygen delivered to the tissue for the case of normoxia and hypoxia are studied, as well as the tissue oxygen delivery during different cooling strategies. The goal of the present study is to understand the effects of temperature in the oxygen uptake, and to determine a safe temperature limits for hypothermic treatment maximizing tissue oxygen delivery. From the calculations it is seen that the oxygen content falls in the vascular and tissue compartments during hypothermia and that this effect is aggravated by hypoxia.

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