Microbubble contrast agents injected into patient’s body increases contrast of ultrasound images. They are encapsulated by a thin layer of surface active materials to prevent their dissolution inside the body. Here we provide a detail procedure of characterizing them by in vitro acoustic experiment and modeling. The encapsulation is modeled as an interface having an intrinsic surface rheology. The rheological parameters are determined by matching the model with measured attenuation. We have characterized contrast agent Definity with surface tension γ, and dilatational viscosity κs. We also the variation of properties with driving frequency.

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