A microfluidic device with an embedded surface-plasmon resonance (SPR) sensor was developed. The detector allows real-time monitoring of chemical processes on-chip. Microfabrication of a poly(dimethylsiloxane) chip incorporating a gold-on-glass nano-hole array (SPR sensor) was developed. This was the first time a SPR sensor operating in transmission mode was built in an on-chip format. Electrokinetic transport phenomena in a microchannel over the gold-on-glass plate was modeled using Computational Fluid Dynamics. The modeling results indicated that the flow over the gold-on-glass plate was pressure driven since there was no variation in electrical potential over the conductor (gold). The flow was electrokinetically driven where an electric field was present. The exchange of solutions in the nano-holes was also modeled and it was found that this process took less than a second. This permeation time is expected to scale with the diffusion coefficient. Lastly, preliminary optical measurements were performed to demonstrate the efficiency of the array of nano-holes as on-chip SPR sensors.

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