An ocular outflow model is proposed to theorize the effect of Schlemm’s canal (SC) and/or collector channel (CC) dilation combined with a trabecular bypass on elevated intraocular pressure (IOP) in glaucomatous eyes. The dilated height of the elliptic SC is largest at the bypass and linearly deceases to the non-dilated height over the dilated circumferential length. The CC dilation is modeled with a reduced outflow resistance of second order polynomial. Equations governing the pressure and flow in SC are solved numerically. The model predicts that the IOP is reduced substantially with moderate dilation from the normal 20 μm to 40 μm at the bypass. SC dilation is more effective for eyes with smaller SC. The dilation of CC can also significantly lower the IOP. With the trabecular bypass alone, the elevated IOP is expected to drop to the mid-to-high teens. The IOP can be further reduced by another 3 to 6 mmHg with moderate SC and CC dilation.
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ASME 2004 International Mechanical Engineering Congress and Exposition
November 13–19, 2004
Anaheim, California, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
0-7918-4703-9
PROCEEDINGS PAPER
Trabecular Bypass: Effect of Schlemm’s Canal and Collector Channel Dilation Available to Purchase
Gregory T. Smedley
Gregory T. Smedley
iinnovations, inc.
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Jianbo Zhou
Glaukos Corporation
Gregory T. Smedley
iinnovations, inc.
Paper No:
IMECE2004-60561, pp. 33-34; 2 pages
Published Online:
March 24, 2008
Citation
Zhou, J, & Smedley, GT. "Trabecular Bypass: Effect of Schlemm’s Canal and Collector Channel Dilation." Proceedings of the ASME 2004 International Mechanical Engineering Congress and Exposition. Advances in Bioengineering. Anaheim, California, USA. November 13–19, 2004. pp. 33-34. ASME. https://doi.org/10.1115/IMECE2004-60561
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