An elastase-induced saccular aneurysm in the rabbit right common carotid artery was developed as a model of human cerebrovascular aneurysm, and used for testing various endovascular devices and therapies. The carotid artery of the rabbit approximates the size of the human middle cerebral artery. Therefore, the created aneurysm is similar to those found in humans around the main branches of the circle of Willis. To minimize the use of animals and gain more insight into the hemodynamics of this model, in addition to the ability to perform early testing of endovascular devices in vitro, we have developed a rapid prototyping technique to produce compliant elastomer replicas of such aneurysms. In this implementation, the geometry of the constructed aneurysm is a representative average. The rapid prototyping system reliably reproduces as many copies of the lumen of the arterial bed out of Polyacrylonitrile-butadiene-styrene (ABS). The ABS output of the prototyping system can be used as a core that is dipped a silicone elastomer and then spin coated until cured. Thereafter, the core is melted away to yield the elastomer replica of the arterial bed. This replica was included in a mock circulation loop for detailed hemodynamic investigation using particle image velocimetry (PIV).
Compliant Silicone Elastomer Models of Elastase-Induced Aneurysms in the Rabbit: Model Construction and Hemodynamics
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Seong, J, Lieber, BB, & Wakhloo, AK. "Compliant Silicone Elastomer Models of Elastase-Induced Aneurysms in the Rabbit: Model Construction and Hemodynamics." Proceedings of the ASME 2004 International Mechanical Engineering Congress and Exposition. Advances in Bioengineering. Anaheim, California, USA. November 13–19, 2004. pp. 15-16. ASME. https://doi.org/10.1115/IMECE2004-59467
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