2D and 3D multi-physics experiment-based nonlinear models with fluid-structure interactions (FSI) and structure-structure interactions (SSI) are introduced to model blood flow and stress/strain distributions in stenotic arteries with lipid pools. Material properties for the vessel and plaque are based on experimental measurements and information available in the literature (Huang et. al., 2001; Tang et. al., 2001). The Navier-Stokes equations are used as the governing equations for the fluid. Mooney-Rivlin models are used for both arteries and lipid cores. A well-tested finite element package ADINA is used to solve the models to perform flow and stress/strain analysis. Our results indicate that artery plaque stress/strain distributions are affected considerably (50%–400% or even more) by vessel material properties, stenosis severity and eccentricity, tube axial pre-stretch, pressure conditions, lipid core material property, size, position and geometry, and fluid-structure and structure-structure (vessel wall and lipid core) interactions. Differences in model assumptions and controlling factor specifications must be taken into consideration when interpreting the significance of computational results.
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ASME 2003 International Mechanical Engineering Congress and Exposition
November 15–21, 2003
Washington, DC, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
0-7918-3710-6
PROCEEDINGS PAPER
Quantifying Effects of Controlling Factors on Flow and Stress Distribution in Stenotic Arteries With Lipid Cores Available to Purchase
Dalin Tang,
Dalin Tang
Worcester Polytechnic Institute, Worcester, MA
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Chun Yang,
Chun Yang
Beijing Normal University, Beijing, China
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Shunichi Kobayashi,
Shunichi Kobayashi
Shinshu University, Nagano, Japan
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David N. Ku
David N. Ku
Georgia Institute of Technology, Atlanta, GA
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Dalin Tang
Worcester Polytechnic Institute, Worcester, MA
Chun Yang
Beijing Normal University, Beijing, China
Shunichi Kobayashi
Shinshu University, Nagano, Japan
David N. Ku
Georgia Institute of Technology, Atlanta, GA
Paper No:
IMECE2003-41113, pp. 53-54; 2 pages
Published Online:
May 12, 2008
Citation
Tang, D, Yang, C, Kobayashi, S, & Ku, DN. "Quantifying Effects of Controlling Factors on Flow and Stress Distribution in Stenotic Arteries With Lipid Cores." Proceedings of the ASME 2003 International Mechanical Engineering Congress and Exposition. Advances in Bioengineering. Washington, DC, USA. November 15–21, 2003. pp. 53-54. ASME. https://doi.org/10.1115/IMECE2003-41113
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