Assessment of in vivo human cartilage loading generally requires computer modeling, since loads usually cannot be directly measured. The utility of these models for assessing knee behavior during complex activities has been limited by the relatively poor quality of experimental data on in vivo knee function. We have developed a method combining high-accuracy knee kinematics (from high-speed stereo-radiography) with subject-specific finite-element models to estimate in vivo cartilage contact pressures during stressful tasks. When applied to ACL reconstruction, significantly higher contact pressures were found in reconstructed knees as compared to the contralateral (uninjured) knees of the same individuals.

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