Cell adhesion to postcapillary vascular endothelium in the fluid dynamic environment is an important event in many physiological and pathological processes, e.g. leukocyte emigration is critical for the successful host defense against tissue injury and infection. Since cell-blood interaction is strongly coupled with cell adhesion in the microchannel, we have developed an integrated mathematical model of cell adhesion, deformation, and rolling. Cells are modeled as elastic solids interacting with the flat wall of a micro-channel. The ligand-receptor bonds between the cell and micro-channel wall are simulated as many simple springs. The formation and dissociation rates of bonds are characterized by a reversible kinetic model (Dembo et al., 1988).

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