Accurate computational modeling of the non-linear, anisotropic mechanical properties of heart valve biomaterials remains an important and challenging area. Unlike phenomenological models, structurally based constitutive models attempt to exploit the tissue composition and structure to avoid ambiguities in material characterization, and offer insight into the function, structure, and mechanics of tissue components. Current finite element (FE) simulations of heart valve biomaterials do not simulate the complete anisotropic mechanical response, limiting simulation realism. In this study, we implemented structural constitutive model developed in our lab that incorporates SALS-derived fiber orientation data. The FE model was validated by both analytical result and experimental data.

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