Quantification of time-dependent changes in three-dimensional morphology of brain structures and neural pathways is a fundamental requirement in studies of neurodevelopment, remodeling and progression of neurological diseases . However, local measures of this kind are extremely difficult due to a lack of clear fiducials. Our motivation to develop a reliable technique to quantify time-dependent changes in neuroanatomy originated with the problem of tracking progression of Niemann-Pick disease type C (NP-C), a heritable disease that causes alterations in brain development .
Deformable Image Registration of Mouse Brain MRI Data Using Hyperelastic Warping
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Veress, AI, Weiss, JA, Gillies, RJ, Bowden, AE, Galons, J, & Rabbitt, RD. "Deformable Image Registration of Mouse Brain MRI Data Using Hyperelastic Warping." Proceedings of the ASME 2002 International Mechanical Engineering Congress and Exposition. Advances in Bioengineering. New Orleans, Louisiana, USA. November 17–22, 2002. pp. 195-196. ASME. https://doi.org/10.1115/IMECE2002-32375
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