Transient one-dimensional distribution of cryoprotectant concentration in pseudobiological tissues (agar) was measured noninvasively using magnetic resonance imaging (MRI). Cryoprotectants were dimethyl sulfoxide (DMSO) and glycerol, common cryoprotectants penetrating cells. Attenuation of MRI image intensity due to volumetric fraction of solution and relaxation times was also investigated. Apparent diffusivity of each cryoprotectant as a function of agar concentration was determined from the inverse problem analysis. The diffusivity decreased with an increase in agar concentration. This method was also applied to the liver tissues of chicken.
- Heat Transfer Division
Measurement of Cryoprotectant Concentration Using MRI in Pseudobiological Tissues and Determination of Diffusivity Based on Inverse Problem Analysis
- Views Icon Views
- Share Icon Share
- Search Site
Ishiguro, H, Kai, T, & Ogawa, K. "Measurement of Cryoprotectant Concentration Using MRI in Pseudobiological Tissues and Determination of Diffusivity Based on Inverse Problem Analysis." Proceedings of the ASME 2002 International Mechanical Engineering Congress and Exposition. Advances in Heat and Mass Transfer in Biotechnology. New Orleans, Louisiana, USA. November 17–22, 2002. pp. 23-27. ASME. https://doi.org/10.1115/IMECE2002-33688
Download citation file: