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Volume 2: Biomedical and Biotechnology Engineering

Biomedical and Biotechnology Engineering

Biotechnology

Parametric Modeling Study of Nanoparticle Penetration Into Spherical Cell Clusters

Konstantin I. Matveev, Thomas T. Goodman, Jingyang Chen, Suzie H. Pun

IMECE 2007; 1-7https://doi.org/10.1115/IMECE2007-41153

Abstract

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Topics: Modeling , Nanoparticles , Tumors , Drug delivery systems , Accounting , Biological tissues , Cancer , Design , Engineering simulation , Particulate matter

Experimental Measurements and Numerical Modeling Validation of Temperature Distribution in Tissue Medium During Short Pulse Laser Irradiation

Ashim Dutta, Kyunghan Kim, Kunal Mitra, Zhixiong Guo

IMECE 2007; 9-16https://doi.org/10.1115/IMECE2007-41295

Abstract

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Topics: Biological tissues , Computer simulation , Irradiation (Radiation exposure) , Lasers , Temperature distribution , Heat conduction , Laser beams , Phantoms , Skin , Bioheat transfer

Molecular Dynamics Simulation Studies of Pore Formation in Lipid Bilayers in the Presence of Dimethylsulfoxide

Dinesh Pinisetty, Raghava Alapati, Dorel Moldovan, Ram V. Devireddy

IMECE 2007; 17-21https://doi.org/10.1115/IMECE2007-41305

Abstract

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Topics: Lipid bilayers , Molecular dynamics simulation , Membranes , Simulation , Fluctuations (Physics) , Nucleation (Physics) , Stress , Equilibrium (Physics) , Fluids , Tension

Intracellular Ice Formation in Cell Suspensions Measured Using a Cryomicroscope and a Calorimeter

Tathagata Acharya, Ram V. Devireddy

IMECE 2007; 23-27https://doi.org/10.1115/IMECE2007-41308

Abstract

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Topics: Ice , Biological tissues , Water , Biological cells , Cryonics , Freezing , Pacific Ocean , Shapes , Stem cells , Thawing

Distribution of WSS on the Internal Carotid Artery With an Aneurysm: A CFD Sensitivity Study

Hyoungsu Baek, Mahesh V. Jayaraman, George Em Karniadakis

IMECE 2007; 29-36https://doi.org/10.1115/IMECE2007-41796

Abstract

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Topics: Aneurysms , Carotid arteries , Computational fluid dynamics , Vessels , Geometry , Turning angles , Blood flow , Blood vessels , Boundary-value problems , Brain

Label-Free and Immobilization-Free Immunoassay

Island Pinnick, Kieseok Oh, Chen-Ling Chang, Kyong-Hoon Lee, Jae-Hyun Chung

IMECE 2007; 37-40https://doi.org/10.1115/IMECE2007-42370

Abstract

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Topics: Drag (Fluid dynamics) , Particulate matter , Radiation counters , Signals , Viscosity

Fluid Manipulation by Bio-Mimetic Cilia

Kieseok Oh, Jae-Hyun Chung, Santosh Devasia, James J. Riley

IMECE 2007; 41-45https://doi.org/10.1115/IMECE2007-42376

Abstract

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Topics: Biomimetics , Fluids , Manufacturing , Plasma desorption mass spectrometry

Non Linear Finite Element Stress Analysis of a Restored Tooth in the Oral Cavity

Rashmi Uddanwadiker, Pramod Padole, Harshwardhan Arya

IMECE 2007; 47-53https://doi.org/10.1115/IMECE2007-42765

Abstract

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Topics: Cavities , Finite element analysis , Stress analysis (Engineering) , Deformation , Stress , Stress concentration , Fracture (Materials) , Fracture (Process) , Risk

A Novel Contamination Free Two Temperature Continuous Flow Polymerase Chain Reactor

Michael B. Sayers, Tara M. Dalton

IMECE 2007; 55-62https://doi.org/10.1115/IMECE2007-43055

Abstract

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Topics: Chain , Contamination , Flow (Dynamics) , Temperature , Annealing , Microfluidics , Drops , Fluids , Aluminum , Biology

A Real-Time Continuous Flow Polymerase Chain Reactor for DNA Expression Quantification

Michael B. Sayers, Tara M. Dalton

IMECE 2007; 63-69https://doi.org/10.1115/IMECE2007-43058

Abstract

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Topics: Chain , DNA , Flow (Dynamics) , Fluorescence , Cycles , Lasers , Electrophoresis , Excitation , Imaging , Matlab

Controlling Nanoparticle Delivery in Hyperthermia for Cancer Treatment: In Vitro Experimental Study

M. Salloum, R. Ma, L. Zhu

IMECE 2007; 71-77https://doi.org/10.1115/IMECE2007-43443

Abstract

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Topics: Cancer , Nanoparticles , Nanofluids , Biological tissues , Particulate matter , Absorption , Heating , Temperature , Agar , Blood vessels

Evaluating the Crack-Tip Bridging Stress in a Bovine Cortical Bone

M. Khandaker, S. Ekwaro-Osire, F. Afrin

IMECE 2007; 79-85https://doi.org/10.1115/IMECE2007-43764

Abstract

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Topics: Bone , Fracture (Materials) , Stress , Fracture toughness , Weight (Mass)

Nano-Cryosurgery: A Basic Way to Enhance Freezing Treatment of Tumor

Jing Liu, Jing-Fu Yan, Zhong-Shan Deng

IMECE 2007; 87-94https://doi.org/10.1115/IMECE2007-43916

Abstract

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Topics: Freezing , Tumors , Biological tissues , Nanoparticles , Cancer , Failure , Heat transfer , Ice , Lung , Modeling

Conformal Tumor Treatment by the Combined Cryosurgical and Hyperthermic System: Optimal Configuration of the Multiple Probes

Zhong-Shan Deng, Jing Liu

IMECE 2007; 95-96https://doi.org/10.1115/IMECE2007-43920

Abstract

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Topics: Probes , Tumors , Biological tissues , Design , Freezing , Heating , Thermodynamic cycles

Computerized Planning of Multi-Probe Cryosurgical Treatment for Tumor With Complex Geometry

Zhong-Shan Deng, Jing Liu

IMECE 2007; 97-101https://doi.org/10.1115/IMECE2007-43921

Abstract

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Topics: Geometry , Probes , Tumors , Freezing , Algorithms , Design , Failure , Optimization

Symposium on Application of Composites in Biomaterials and Bioengineering

The Effects of Tibiofemoral Angle and Body Weight on the Stress Field in the Knee Joint

Nicholas H. Yang, H. Nayeb-Hashemi, Paul K. Canavan

IMECE 2007; 103-111https://doi.org/10.1115/IMECE2007-41344

Abstract

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Topics: Knee , Stress , Weight (Mass) , Cartilage , Finite element analysis , Cycles , Osteoarthritis , Stress concentration , Biomechanics , Bone

Gradients of Stiffness Guide Neurite Growth in 3D Collagen Gels

Harini G. Sundararaghavan, David I. Shreiber

IMECE 2007; 113-119https://doi.org/10.1115/IMECE2007-41873

Abstract

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Topics: Stiffness , Mechanical properties , Wounds , Anisotropy , Biomaterials , Bridges (Structures) , Fluorescence , Microfluidics , Patient treatment , Shear modulus

Dynamic Analysis of Soft Tissue Viscoelasticity Under Ultrasonic Radiation Force Using FEM

Megan L. Kogit, Baoxiang Shan, Assimina A. Pelegri

IMECE 2007; 121-125https://doi.org/10.1115/IMECE2007-42013

Abstract

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Topics: Dynamic analysis , Finite element methods , Finite element model , Radiation (Physics) , Soft tissues , Viscoelasticity , Damping , Finite element analysis , Young's modulus , Acoustics

Mapping of Regional Cancerous Tissue Mechanical Property Changes Using Harmonic Motion Imaging

Caroline Maleke, Jianwen Luo, Assimina A. Pelegri, Elisa E. Konofagou

IMECE 2007; 127-133https://doi.org/10.1115/IMECE2007-42294

Abstract

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Topics: Biological tissues , Harmonic motion , Imaging , Mechanical properties , Tumors , Ablation (Vaporization technology) , Displacement , Echoes , Transducers , Cancer

Modeling and Characterization of Biomaterials Spreading Properties in Powder-Based Rapid Prototyping Techniques

Yaser Shanjani, Ehsan Toyserkani, Christina Wei

IMECE 2007; 135-143https://doi.org/10.1115/IMECE2007-42530

Abstract

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Topics: Biomaterials , Modeling , Rapid prototyping , Rollers , Friction , Pressure , Compacting , Constitutive equations , Coulombs , Density

Investigation of the Nanomechanical and Tribological Properties of Tooth-Fillings Materials

Marwan Al-Haik, Shane Trinkle, Hartono Sumali, Daniel Garcia, Fan Yang, Ulises Martinez, Scott Miltenberger

IMECE 2007; 145-151https://doi.org/10.1115/IMECE2007-42975

Abstract

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Topics: Amalgams , Biocompatibility , Design , Elastic moduli , Enameling , Epoxy adhesives , Epoxy resins , Fillers (Materials) , Mechanical behavior , Mechanical properties

Prediction of Biomechanical Properties of Bone Implant Scaffolds

Yaser Shanjani, Naveen Chandrashekar, Ehsan Toyserkani

IMECE 2007; 153-159https://doi.org/10.1115/IMECE2007-43001

Abstract

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Topics: Biomechanics , Bone , Porosity , Stiffness , Biomaterials , Finite element analysis , Manufacturing , Materials properties , Modeling , Poisson ratio

Symposium on Applications of Micro- and Nanosystems in Medicine and Biology

A Biaxial Shape Memory Alloy Actuated Cell/Tissue Stretching System

Yingfeng Shan, Jacob Dodson, Sheena Abraham, John E. Speich, Raj Rao, Kam K. Leang

IMECE 2007; 161-169https://doi.org/10.1115/IMECE2007-42266

Abstract

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Topics: Biological tissues , Shape memory alloys , Design , Atomic force microscopy , Membranes , Actuators , Alloys , Anisotropy , Blood vessels , Control equipment

Modeling of a Circular Magnetic-Fluid Deformable Mirror for Ophthalmic Applications

Azhar Iqbal, Devina Dukhu, Foued Ben Amara

IMECE 2007; 171-178https://doi.org/10.1115/IMECE2007-42399

Abstract

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Topics: Magnetic fluids , Mirrors , Modeling , Imaging , Optics , Control systems , Design , Geometry , Human eye , Optical elements

Multiple Annular Ring Capacitive Micromachined Ultrasonic Transducer Arrays for Forward-Looking Intravascular Ultrasound Imaging Catheters

Rasim O. Guldiken, Jaime Zahorian, Mujdat Balantekin, Mustafa Karaman, F. Levent Degertekin

IMECE 2007; 179-180https://doi.org/10.1115/IMECE2007-42493

Abstract

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Topics: Aluminum , Catheters , Complementary metal oxide semiconductors , Echoes , Electronics , Imaging , Micromachining , Optimization , Polishing equipment , Signal to noise ratio

Wet Etched Pyramidal Microneedles With Fluid-Delivery Microchannels

Michael S. Diehl, Brian D. Jensen

IMECE 2007; 181-182https://doi.org/10.1115/IMECE2007-43524

Abstract

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Topics: Fluids , Microchannels , Microneedles , Drugs , Skin , Absorption , Drug delivery systems , Needles

Symposium on Bio Engineering/Medical Applications

Controlled Cavitation and Sonoporation in Microfluidics

Claus-Dieter Ohl, Se´verine Le Gac, Ed Zwaan, Kinko Tsuji, Albert van den Berg

IMECE 2007; 183-185https://doi.org/10.1115/IMECE2007-41102

Abstract

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Topics: Cavitation , Microfluidics , Bubbles , Flow (Dynamics) , Reynolds number , Biological cells , Collapse , Dynamics (Mechanics) , Fluid dynamics , Fluids

Biomechanical Evaluation of In-Stenting Restenosis

Linxia Gu, Aswini K. Muttyam

IMECE 2007; 187-190https://doi.org/10.1115/IMECE2007-41280

Abstract

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Topics: Atherosclerosis , Biomechanics , Collapse , Coronary arteries , Design , Diseases , Geometry , Stents , Stress , Struts (Engineering)

Influence of Pulse Repetition Rate on Cavitation at the Surface of an Object Targeted by Lithotripter Shock Waves

Yuri A. Pishchalnikov, Mark M. Kaehr, James A. McAteer

IMECE 2007; 191-200https://doi.org/10.1115/IMECE2007-41387

Abstract

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Topics: Cavitation , Lithotripters , Shock waves , Bubbles , Stress , Collapse , Density , Dynamics (Mechanics) , Imaging , Waves

The Development of Endodontic Micro Robot

J. Dong, H. Everett

IMECE 2007; 201-204https://doi.org/10.1115/IMECE2007-41562

Abstract

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Topics: Biological tissues , Canals , Computers , Design engineering , Drilling , Drills (Tools) , Errors , Innovation , Machinery , Patient treatment

Post Healing Structural Response of an Internal Fixation System for a Mid-Shaft Radius Fracture

Cameron Coates, Camille Coates-Clark, Mykal Woody

IMECE 2007; 205-210https://doi.org/10.1115/IMECE2007-41600

Abstract

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Topics: Bone , Fatigue analysis , Finite element methods , Finite element model , Fracture (Materials) , Fracture (Process) , Geometry , Hardware , Manufacturing , Mechanical properties

Simulation of Blast-Head Interactions to Study Traumatic Brain Injury

M. Sotudeh Chafi, G. Karami, M. Ziejewski

IMECE 2007; 211-220https://doi.org/10.1115/IMECE2007-41629

Abstract

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Topics: Fluid structure interaction , Pressure , Shear stress , Simulation , Traumatic brain injury

Finite Element Modeling of Brain Tissue Retraction for Neurosurgical Simulation

Kazuhiko Adachi, Yoshiaki Inoue, Hiroshi Kanki, Atsushi Fujita, Eiji Kohmura

IMECE 2007; 221-227https://doi.org/10.1115/IMECE2007-41772

Abstract

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Topics: Biological tissues , Brain , Finite element analysis , Modeling , Neurosurgery , Simulation , Surgery

Effects of Acceleration Amplitude and Frequency of Mechanical Vibration on Osteoblast-Like Cells

Tetsuo Shikata, Toshihiko Shiraishi, Kumiko Tanaka, Shin Morishita, Ryohei Takeuchi

IMECE 2007; 229-236https://doi.org/10.1115/IMECE2007-41797

Abstract

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Topics: Osteoblasts , Vibration , Bone , Density , Plates (structures) , Aluminum plate , Carbon dioxide , Chain , Excitation , Excitation systems

Parameter Estimation of the Human Ankle in the Transverse Plane During the Initiation of a Turn

Brian C. Glaister, Jason A. Schoen, Michael S. Orendurff, Glenn K. Klute

IMECE 2007; 237-240https://doi.org/10.1115/IMECE2007-42342

Abstract

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Topics: Biomimetics , Control systems , Dampers , Damping , Design , Design engineering , Parameter estimation , Prostheses , Springs , Stiffness

Low Cost Adaptive Optics System for Retinal Imaging

Maurizio Ficocelli, Azhar Iqbal, Foued Ben Amara

IMECE 2007; 241-249https://doi.org/10.1115/IMECE2007-42391

Abstract

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Topics: Optics , Retinal imaging , Mirrors , Design , Diseases , Membranes , Microelectromechanical systems , Actuators , Closed loop systems , Computers

An MRI Based Study of Tarsal Development During Manipulation and Casting Therapy of Infant Clubfoot

Roza Mahmoodian, Sorin Siegler

IMECE 2007; 251-261https://doi.org/10.1115/IMECE2007-42573

Abstract

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Topics: Casting , Magnetic resonance imaging , Patient treatment , Shapes , Computers , Deformation , Performance , Rotation , Stress , Surgery

Computational Simulation of Non-Newtonian Blood Flow in Carotid Bifurcation for Investigating the Various Rheological Blood Models

E. Jahanyfard, B. Firoozabadi, A. Goodarzvand Chegini

IMECE 2007; 263-270https://doi.org/10.1115/IMECE2007-42692

Abstract

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Topics: Bifurcation , Blood , Blood flow , Rheology , Simulation

Micro Particle Transport and Deposition in Human Upper Airways

Jim S. Chen, Jinho Kim

IMECE 2007; 271-280https://doi.org/10.1115/IMECE2007-42928

Abstract

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Topics: Aerosols , Air flow , Bifurcation , Computational fluid dynamics , Computer software , Density , Design , Drag (Fluid dynamics) , Drugs , Flow (Dynamics)

Comparison of Stone Comminution Produced by Two Different Reflector Configurations in an HM-3 Lithotripter

Jun Qin, W. Neal Simmons, Pei Zhong

IMECE 2007; 281-284https://doi.org/10.1115/IMECE2007-43061

Abstract

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Topics: Lithotripters , Size reduction (Materials) , Pressure , Acoustics , Membranes , Performance , Shock (Mechanics) , Design , Shock waves

Non-Spherical Collapse of an Air Bubble Subjected to a Lithotripter Pulse

Eric Johnsen, Tim Colonius, Wayne Kreider, Michael R. Bailey

IMECE 2007; 285-294https://doi.org/10.1115/IMECE2007-43156

Abstract

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Topics: Bubbles , Collapse , Lithotripters , Cavitation , Pressure , Shock (Mechanics) , Shock waves , Computer simulation , Flow (Dynamics) , Jets

Design of Biomechanical Testing Methods and Metrics to Evaluate the Performance of Synthetic Spinal Implants Versus Bone Graft for Lumbar Corpectomy

P. Huang, N. Sarigul-Klijn, S. Hazelwood, M. Gupta, R. Roberto

IMECE 2007; 295-299https://doi.org/10.1115/IMECE2007-43319

Abstract

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Topics: Biomechanics , Bone , Design , Spinal implants , Testing , Stability , Complex systems , Failure , Human spine , Mechanical testing

A Model-Independent Technique for Eigenvalue Identification and Its Application in Predicting Cardiac Alternans

Xiaopeng Zhao, David G. Schaeffer, Wanda Krassowska, Daniel J. Gauthier

IMECE 2007; 301-302https://doi.org/10.1115/IMECE2007-43380

Abstract

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Topics: Eigenvalues

Effects of Tandem Pulse on Stone Comminution in an Electromagnetic Shock Wave Lithotripter

Nathan Smith, W. Neal Simmons, Georgy N. Sankin, Pei Zhong

IMECE 2007; 303-305https://doi.org/10.1115/IMECE2007-43582

Abstract

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Topics: Lithotripters , Shock waves , Size reduction (Materials) , Delays , Design , Optimization , Pressure , Shock (Mechanics)

Guidelines for Controlling Pore Radii From Nonlinear Analysis of a Two-Dimensional Model of Electroporation

Jonathan P. Cranford, Xiaopeng Zhao, Wanda Krassowska

IMECE 2007; 307-308https://doi.org/10.1115/IMECE2007-43585

Abstract

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Topics: Electroporation

FE Modeling of the Three-Layer Human Carotid Artery Under Impact Loadings

Aihong Zhao, Ken Digges, Mark Field, David Richens

IMECE 2007; 309-319https://doi.org/10.1115/IMECE2007-43955

Abstract

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Topics: Biomechanics , Carotid arteries , Finite element analysis , Fluids , Modeling

Dynamics of Single Cavitation Bubble Oscillation Inside an Elastic Tube

Georgy N. Sankin, Pei Zhong

IMECE 2007; 321-322https://doi.org/10.1115/IMECE2007-43991

Abstract

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Topics: Bubbles , Cavitation , Dynamics (Mechanics) , Oscillations , Ultrasound , Biological tissues , Blood vessels , Biomembranes , Displacement , Imaging

HIFU-Induced Gene Activation in a Cell-Embedded Tissue Mimicking Phantom

Fang Yuan, Chris Pua, Pei Zhong, Yunbo Liu

IMECE 2007; 323-324https://doi.org/10.1115/IMECE2007-43996

Abstract

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Topics: Biological tissues , Phantoms , Patient treatment , Tumors , Ablation (Vaporization technology) , Cancer , Dosimetry , Temperature distribution , Thermal stresses , Transparency

Symposium on Vibrations and Acoustics in Biomedical Applications

Modified Fading Memory Model to Describe ASM Dynamics

Y. Du, A. M. Al-Jumaily

IMECE 2007; 327-329https://doi.org/10.1115/IMECE2007-41179

Abstract

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Topics: Dynamics (Mechanics) , Bridges (Structures) , Muscle , Oscillations

An Interactive Lung Model for Pressure Oscillation Assessment

Prasika I. Reddy, Ahmed M. Al-Jumaily

IMECE 2007; 331-332https://doi.org/10.1115/IMECE2007-41193

Abstract

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Topics: Lung , Oscillations , Pressure , Bifurcation , Respiratory system

Vocal Fold Dynamics During Phonations

H. Lan, A. M. Al-Jumaily, A. Mirnajafi

IMECE 2007; 333-335https://doi.org/10.1115/IMECE2007-41456

Abstract

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Topics: Dynamics (Mechanics) , Vocal cords , Collisions (Physics) , Computer software , Finite element model , Risk , Stress

An Analysis of Laminated Piezoelectric Infinite Plate for Broadband Biomedical Ultrasound Transducer Design

Daniel H. Cortes, Sam M. Mukdadi

IMECE 2007; 337-340https://doi.org/10.1115/IMECE2007-42289

Abstract

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Topics: Biomedical ultrasonics , Design , Transducers , Displacement , Waveguides , Boundary-value problems , Anisotropy , Circuits , Emission spectroscopy , Finite element analysis