Research has suggested that elevated intracranial pressure (ICP) can cause damage to the optic nerve and reduce visual acuity. There is a need for noninvasive ICP monitoring devices. A simple, portable device capable of measuring relative changes in ICP using a noninvasive methodology would have a significant impact on clinical care. The methodology presented in this paper utilizes transcranial Doppler ultrasonography to monitor ophthalmic artery hemodynamics while small forces are applied to cornea. In vivo testing using a porcine model results in a correlation between pulsatility or resistivity indices and ICP levels. Specifically, the change in these indices while force is applied decreases as ICP increases. The data collection prototype used in these experiments contained an ultrasound transducer instrumented with a load cell to measure force applied to the cornea. These experiments are an initial step towards adapting the data collection prototype into a handheld noninvasive ICP monitoring device.
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ASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference
August 2–5, 2015
Boston, Massachusetts, USA
Conference Sponsors:
- Design Engineering Division
- Computers and Information in Engineering Division
ISBN:
978-0-7918-5710-6
PROCEEDINGS PAPER
In Vivo Testing of Noninvasive ICP Monitoring Methodology in a Porcine Model
Jeff A. Hawks,
Jeff A. Hawks
University of Nebraska, Lincoln, NE
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Chase Pfeifer,
Chase Pfeifer
University of Nebraska, Lincoln, NE
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Greg Bashford,
Greg Bashford
University of Nebraska, Lincoln, NE
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William Thorell,
William Thorell
University of Nebraska Medical Center, Omaha, NE
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James Gigantelli
James Gigantelli
University of Nebraska Medical Center, Omaha, NE
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Jeff A. Hawks
University of Nebraska, Lincoln, NE
Chase Pfeifer
University of Nebraska, Lincoln, NE
Max Twedt
University of Nebraska, Lincoln, NE
Greg Bashford
University of Nebraska, Lincoln, NE
William Thorell
University of Nebraska Medical Center, Omaha, NE
James Gigantelli
University of Nebraska Medical Center, Omaha, NE
Paper No:
DETC2015-47655, V003T14A013; 7 pages
Published Online:
January 19, 2016
Citation
Hawks, JA, Pfeifer, C, Twedt, M, Bashford, G, Thorell, W, & Gigantelli, J. "In Vivo Testing of Noninvasive ICP Monitoring Methodology in a Porcine Model." Proceedings of the ASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. Volume 3: 17th International Conference on Advanced Vehicle Technologies; 12th International Conference on Design Education; 8th Frontiers in Biomedical Devices. Boston, Massachusetts, USA. August 2–5, 2015. V003T14A013. ASME. https://doi.org/10.1115/DETC2015-47655
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