Biological cell injection is a sensitive and important work which is implemented in injection of foreign materials into individual cells. Microinjection is significantly developed in the field of drug discovery and genetics so predicting the behavior of cell in microinjection is remarkably important because a tiny excessive manipulation force can destroy the tissue of the biological cell. There are a few analytical methods available to simulate the cell injection, hence the numerical methods such as FEM are suitable to be used to model the microinjection. In this study, a new spherical super element is presented to model the biological cells and deformation of a specific cell under an external force is performed. The relationship between the injection force and the deformation of biological cell is demonstrated by using super element formulations. For validating the model, results are compared with findings of analytical and experimental methods. The advantage of this element is that only a few super elements can predict the static behavior of biological cell in microinjection properly instead of implementing a large number of conventional elements, so using the super element to model the cell can decrease the run time with suitable accuracy.
- Design Engineering Division and Computers and Information in Engineering Division
Application of a New Spherical Super Element in Predicting the Deformation of Biological Cells in Microinjection
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Sarvi, MN, & Ahmadian, MT. "Application of a New Spherical Super Element in Predicting the Deformation of Biological Cells in Microinjection." Proceedings of the ASME 2011 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. Volume 7: 5th International Conference on Micro- and Nanosystems; 8th International Conference on Design and Design Education; 21st Reliability, Stress Analysis, and Failure Prevention Conference. Washington, DC, USA. August 28–31, 2011. pp. 41-49. ASME. https://doi.org/10.1115/DETC2011-47653
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