The goal of this investigation is to develop a simulation-based control strategy to eliminate flow-maldistribution in parallel microchannels. An accurate simulation of fluid flow through parallel microchannels is achieved by utilizing a fictitious domain representation of immersed objects, such as microvalves and bubbles. System identification techniques are employed to produce a lower dimensional model that captures the essential dynamics of the full nonlinear flow, in terms of a relationship between the valve angles and the exit flow rate for each channel. The resulting linear model is incorporated into a model predictive control scheme to identify flow maldistribution from exit flow velocities and prescribe actuation of channel valves to effectively redistribute the flow. Flow simulations in a three parallel microchannel geometry including bubbles illustrates the effectiveness of the control design, which quickly and efficiently varies channel valves to remove the bubble and equalize the flow rates in each channel.

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