Currently, blade manufacturers employ in-house histology testing to evaluate the performance of their blades. The following performance metrics are evaluated for a group of production blades: sample compression, cut-feel, and number of knife lines left on samples. In the research presented herein, an evaluation of the relationships between high quality samples and microtome knife configuration variables is explored through quantifying the cutting force and inspecting samples for knife induced defects. Several types of measurements correlating to the cutting force were made. Sound, vibration, and cutting force were tested for their adequacy in distinguishing different knife configurations. The most robust measurement was then focused on to derive relationships between blade types and microtome setup. An automated imaging system was explored for measurement of sample quality. The imaging system can improve the reliability and productivity of the measurement of knife quality metrics, for product-process quality control. The imaging system achieves this by detecting knife lines and performing simple measurements to quantify the degree of compression of the samples. This study aims to advance the science of histology and give insight to blade manufacturers through interfacing a microtome with a PC based user interface.
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ASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference
August 30–September 2, 2009
San Diego, California, USA
Conference Sponsors:
- Design Engineering Division and Computers in Engineering Division
ISBN:
978-0-7918-4898-2
PROCEEDINGS PAPER
Integrated Cut Performance and Sample Inspection System for Microtome Setup Evaluation Available to Purchase
Daniel Brisach,
Daniel Brisach
University of Delaware, Newark, DE
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Justin Alms,
Justin Alms
University of Delaware, Newark, DE
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James Glancey,
James Glancey
University of Delaware, Newark, DE
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Nate Cloud
Nate Cloud
Cirrus Engineering, Newark, DE
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Daniel Brisach
University of Delaware, Newark, DE
Justin Alms
University of Delaware, Newark, DE
James Glancey
University of Delaware, Newark, DE
Nate Cloud
Cirrus Engineering, Newark, DE
Paper No:
DETC2009-87521, pp. 145-152; 8 pages
Published Online:
July 29, 2010
Citation
Brisach, D, Alms, J, Glancey, J, & Cloud, N. "Integrated Cut Performance and Sample Inspection System for Microtome Setup Evaluation." Proceedings of the ASME 2009 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. Volume 1: 22nd Biennial Conference on Mechanical Vibration and Noise, Parts A and B. San Diego, California, USA. August 30–September 2, 2009. pp. 145-152. ASME. https://doi.org/10.1115/DETC2009-87521
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