A micro-array based automated hybridization platform, ITRI HybOne, with the throughput rate of 12-sets per lot has been proposed and developed for whole human genome expression profiling test. A special handling module has been designed for capturing of Whole Human Genome Micro-array which is a glass slide 75mm in length and 25mm in width and 1mm in thickness. According to the user-defined protocol, an operator can set the heating temperature, washing temperature, heating hours and washing hours before starting the profiling test. Operator inputs target samples and micro-arrays to ITRI HybOne, pushes the Cycle-Start button to start. With the help of the handling module and other automatic devices, after hours of automatic process, the micro-arrays are ready for profile scanning. All the handling modules used in the platform are recycled for next profiling test.

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