For radioactive material packages railway transportation, a reliable fastening system of the packages in the wagon is the key to realize safe and efficient transportation. The following types of fastening systems are mainly used in the railway transportation for small radioactive material packages, such as stopper reinforcement, rope reinforcement, bolt reinforcement, freight container loading and reinforcement, etc. The fastening system should be determined according to the size, shape, weight and other parameters of different packages. In that case, the requirements of convenient operation could be considered while ensuring the reinforcement strength. Combined with the examples of different types of radioactive material packages, some examples of reasonable fastening systems for railway transportation were introduced. In order to ensure the safety, the strength of reinforcement materials should be calculated and verified, and the transportation stability of wagon loaded with packages should be analyzed.