To ensure nuclear safety and prevent or mitigate the consequences of accidents, many safety systems have been set up in nuclear power plants to limit the consequences of accidents. Even though technical specifications based on deterministic safety analysis are applied to avoid serious accidents, they are too poor to handle multi-device managements compared with configuration risk management which computes risks in nuclear power plants based on probabilistic safety assessment according to on-going configurations. In general, there are two methodologies employed in configuration risk management: living probabilistic safety assessment (LPSA) and risk monitor (RM). And average reliability databases during a time of interest are employed in living probabilistic safety assessment, which may be naturally applied to make long-term or regular management projects. While transient risk databases are involved in risk monitor to measure transient risks in nuclear power plants, which may be more appropriate to monitor the real-time risks in nuclear power plants and provide scientific real-time suggestions to operators compared with living probabilistic safety assessment. And this paper concentrates on the applications and developments of living probabilistic safety assessment and risk monitor which are the mainly foundation of the configuration risk management to manage nuclear power plants within safe threshold and avoid serious accidents.