For the thermal hydraulic and safety analysis of nuclear reactor, a lot of theoretical models and engineering experience are mainly contained in the design software. The degree of self-reliance of software directly reflects the technological level and core competencies. According to the nuclear power plant (NPP) design requirements, self-reliant thermal hydraulic and safety analysis software, such as CORTH, TRANTH, PHYCA and etc., have been developed by Nuclear Power Institute of China (NPIC) with reasonable planning and scientific implementation. In this paper, the development process of the self-reliant software is reviewed, covering requirement analysis, model research, software design, coding, testing, verification and validation. And the main characteristics of self-reliant software were summarized. The successful development of thermal hydraulic and safety analysis software support the export of nuclear power units of China, and enhance the competitiveness.

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