Gamma camera imaging technology is a non-destructive passive radiation imaging technology, which can quickly find the unknown source location, search the exact number of radioactive sources and relative intensity. Therefore, it is very important and widely used in the fields of effective regulation of radioactive sources, handling of various nuclear emergencies, nuclear arms control and other fields. In the practical application of gamma camera, it often faces the imaging difference caused by the difference of radiation source intensity, detection time and detection distance. It is helpful to study the change of imaging characteristics under different experimental conditions for the practical application of gamma camera under different scenes. In this paper, the structure and imaging principle of gamma camera are analyzed in detail. Using the Cartogam portable gamma camera, a set of comparative experiments are carried out to study the time characteristics, distance characteristics and source intensity characteristics of the gamma camera. The results show that the imaging quality of gamma camera is positively correlated with the time source intensity, negatively correlated with the distance. For a milliCurie source, the gamma camera has very good fast-position resolution at a distance of 1 meter from the radioactive source and can form a more complete hot spot image within 5 minutes. When the distance becomes larger, the radioactive source needs at least 20 minutes to form a more accurate hot spot image. The hot spot is no longer as complete as a concentric circle structure, but can achieve precise positioning. For a strong source of more than ten milliCurie, immediate imaging within two minutes can be basically achieved within two meters. Under multi-source conditions, when the source intensities differ greatly and the distance between sources is relatively close, the detection of weak source can not be achieved by increasing the measurement time. However, by observing the counting images in a short period of time, the possibility of existence of a weak source can be deduced. Therefore, in the practical application of the gamma camera, it is necessary to constantly adjust its imaging conditions to ensure the detection of weak source verification. In this paper, the Monte Carlo model of gamma camera is set up to simulate the imaging. Compared with the actual imaging hot spots, the simulated images can correctly reflect the hot spot graph’s level distribution, which has the value of further research.

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