Best estimate plus uncertainty methods (BEPUs) could be used to eliminate the over-conservatism and gain more safety margin in the analysis of thermal-hydraulic transient process at nuclear power plant. Based on the Best estimate thermal-hydraulic system code RELAP5/MOD3.2 platform, the best estimate plus uncertainty methods (BEPUs) proposed by GRS (Gesellschaft fur Anlagen- and Reaktorsicherheit) are presented together with applications to a small break loss of coolant accident (SB-LOCA) on the AP1000 Nuclear Power Plant best estimate analysis model. According to the results of uncertainty calculations, the dispersion bands of maximum cladding temperature and the core outlet void fraction are displayed and assessed.

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