Supercritical carbon dioxide (S-CO2) cycles are recently very perspective and are researched all around the world. For successful deployment of these cycles experimental research is necessary. This paper describes the design and research program of S-CO2 experimental loop that was performed in collaboration of the Czech Technical University in Prague (CTU) and the Research Centre Rez i.n.c.. The loop will be constructed at the premises of the Research Centre Rez i.n.c a part of the project SUSEN. This paper particularly focuses on the design of components, their thermotechnical calculations, construction and arrangement of the experimental loop. It also deals with the preparation of experimental measurements to be implemented. The loop is envisioned for the research of the heat transfer for various operating conditions, testing of the material in the environment of S-CO2 and sampling of gas from the loop.

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