The single droplet phase change model during motion is developed based on the phenomena description and mechanism comprehension, which including the droplet phase change model as well as the droplet motion model. Then, the calculation of the droplet phase change characteristics during moving in the uniform flow in the gravity separation space is conducted. The results show that when the droplet are evaporating during its moving, the radius will decrease continuously and it will be carried more easily by the steam vapor, which will lead to the larger separation radii of the droplets and the reduced the gravity separation efficiency. In addition, this paper shows the three-dimensional map for the critical separation over the pressure difference and the steam vapor flow velocity, which can contribute to forecast the influence of the droplet phase change on the separation characteristics. The results can be applied in the design of the steam-water separation plants.