Integrated method for constructing proactive trouble prevention knowledge base has been studied before starting the practical system development towards various application areas of knowledge base system for failure modes and effect analysis (FMEA), fault tree analysis (FTA), and so forth. In this paper, basic ideas of configuring the structured knowledge based systemization to be used for such purpose are summarized with the following order: (i) Effective re-use of various trouble information, (ii) Method of structuralizing trouble knowledge, (iii) Knowledge on trouble prediction and proactive prevention, (iv) Description of energy, mass and information flow by multilevel flow model, and (v) Method of knowledge base systemization.

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