Acoustic-structural-electromagnetic coupled models have been successfully set up for Resonant Acoustic Chambers (RACs) which have important applications in radiation detection, sonoluminescence and sonofusion; the goal being to simulate transient acoustically driven metastable states and structural responses so that the designs of RACs can be optimized for advanced applications. The simulation predictions have been benchmarked with experimental data in two designs of RACs, Open Chamber System (OCS) and Closed Chamber System (CCS). A framework was developed for benchmarking and validating the predicted resonant frequency and oscillatory pressure mapping profiles with and without scattering centers. Experiments were conducted with and without external neutron-induced cavitation bubble clusters. Comparison of measurements versus experimental data demonstrated the applicability of the modeling-cum-simulation framework. Studies have provided insights into the significant and complex influences of fluid-structure-electromagnetic coupling and on the influence of scattering center inclusions on the system’s acoustic responses. The framework appears reasonable for design of advanced, high-powered RACs; however, significant technical challenges remain for capturing the overall system performance upon evolution and transport of transient bubble clusters.

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