Artificial Neural Network (ANN) with its self-learning capabilities, nonlinear mapping ability and generalization ability, has been widely applied for fault diagnosis of complex system like Nuclear Power Plant (NPP). In this paper, an overview of the application of supervised multi-layer feed-forward neural network for fault diagnosis of NPP is presented, including the following aspects: the acquisition of the training sample data, the determination of appropriate input and output data, the choice of hidden layer structure and the evaluation of network model performance. Finally, a number of key issues about the engineering application of neural network fault diagnosis in practice were discussed.

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