Production of fine chemicals and pharmaceuticals often includes solid-liquid suspension flow. For continuous cooling a tubular crystallizer was designed based on the coiled flow inverter (CFI) concept, providing a narrow residence time distribution (RTD) of the liquid phase. Counter-current cooling allows for a smooth adjustment of the axial temperature profile. Successful operation of up to 50 g min−1 in a prototype with 4 mm inner diameter was scaled down to a tube-in-tube CFI crystallizer (CFIC) with an inner diameter of 1.6 mm and varying length from 7.8 to 54.6 m. This leads to a significantly lower consumption of chemicals in process development with lower total mass flow rates of 15–20 g min−1. Due to modular design, mean residence time (3.8 to 6.9 min) and mean cooling rate (0.6 to 1.4 K·min−1) were varied at constant mass flow rate. Crystallization growth rate and yield are analyzed with the L-alanine/water test system and seed crystals of 125–180 μm.
- Fluids Engineering Division
Miniaturized Tubular Cooling Crystallizer With Solid-Liquid Flow for Process Development
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Schmalenberg, M, Hohmann, L, & Kockmann, N. "Miniaturized Tubular Cooling Crystallizer With Solid-Liquid Flow for Process Development." Proceedings of the ASME 2018 16th International Conference on Nanochannels, Microchannels, and Minichannels. ASME 2018 16th International Conference on Nanochannels, Microchannels, and Minichannels. Dubrovnik, Croatia. June 10–13, 2018. V001T02A006. ASME. https://doi.org/10.1115/ICNMM2018-7660
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