Thermoplastics have been increasingly employed for microfluidic devices due to their manufacturability, low cost, and biocompatibility. A microfluidic device consists of a number of necessary building blocks, including microvalves that are often used for flow regulation. The state-of-the-art of the microfluidic valve technology is polydimethylsiloxane (PDMS)-based elastic membrane valve. This paper is to report the integration of the elastomer valve into a thermoplastic device. The valves were designed for a two-dimensional protein separation device, which was fabricated from cyclic olefin copolymers (COC). To realize the goal of integrating the elastomer-based valves in the device, the key challenge is to achieve strong bonding between COC and PDMS so that the device will not delaminate when a pressure is built up after the valves are closed. Microvalve arrays were fabricated in a COC/PDMS/COC device to facilitate the introduction of two types of separation media, without cross-contamination, into orthogonal channels in order to achieve two-dimensional separation. In addition, we studied thermal actuation in the microvalve, as an alternative to pneumatic actuation in the conventional PDMS-based elastomer valve. The thermally actuated valves can be self-contained, requiring less-bulky external accessories than pneumatically actuated valves.
Skip Nav Destination
ASME 2012 10th International Conference on Nanochannels, Microchannels, and Minichannels collocated with the ASME 2012 Heat Transfer Summer Conference and the ASME 2012 Fluids Engineering Division Summer Meeting
July 8–12, 2012
Rio Grande, Puerto Rico, USA
Conference Sponsors:
- Heat Transfer Division
- Fluids Engineering Division
ISBN:
978-0-7918-4479-3
PROCEEDINGS PAPER
Microfluidic Valve Arrays in Thermoplastic Devices
Z. Hugh Fan,
Z. Hugh Fan
University of Florida, Gainesville, FL
Search for other works by this author on:
Shancy Augustine,
Shancy Augustine
University of Florida, Gainesville, FL
Search for other works by this author on:
Harvy Freitag,
Harvy Freitag
University of Florida, Gainesville, FL
Search for other works by this author on:
Toshikazu Nishida
Toshikazu Nishida
University of Florida, Gainesville, FL
Search for other works by this author on:
Z. Hugh Fan
University of Florida, Gainesville, FL
Pan Gu
University of Florida, Gainesville, FL
Shancy Augustine
University of Florida, Gainesville, FL
Ke Liu
University of Florida, Gainesville, FL
Harvy Freitag
University of Florida, Gainesville, FL
Toshikazu Nishida
University of Florida, Gainesville, FL
Paper No:
ICNMM2012-73021, pp. 453-458; 6 pages
Published Online:
July 22, 2013
Citation
Fan, ZH, Gu, P, Augustine, S, Liu, K, Freitag, H, & Nishida, T. "Microfluidic Valve Arrays in Thermoplastic Devices." Proceedings of the ASME 2012 10th International Conference on Nanochannels, Microchannels, and Minichannels collocated with the ASME 2012 Heat Transfer Summer Conference and the ASME 2012 Fluids Engineering Division Summer Meeting. ASME 2012 10th International Conference on Nanochannels, Microchannels, and Minichannels. Rio Grande, Puerto Rico, USA. July 8–12, 2012. pp. 453-458. ASME. https://doi.org/10.1115/ICNMM2012-73021
Download citation file:
7
Views
Related Proceedings Papers
Related Articles
Nanofiber Covered Stent (NCS) for Vascular Diseases
J. Med. Devices (June,2008)
Biocompatible Ionic Liquids: A New Approach for Stabilizing Proteins in Liquid Formulation
J Biomech Eng (July,2009)
Modeling and Experimental Characterization of Pressure Drop in Gravity-Driven Microfluidic Systems
J. Fluids Eng (February,2015)
Related Chapters
Conclusions
Chitosan and Its Derivatives as Promising Drug Delivery Carriers
Surface Analysis and Tools
Tribology of Mechanical Systems: A Guide to Present and Future Technologies
Synthesis and Characterization of Carboxymethyl Chitosan Based Hybrid Biopolymer Scaffold
International Conference on Mechanical and Electrical Technology, 3rd, (ICMET-China 2011), Volumes 1–3