Pulsatile laminar-turbulent transitional flow in a three-dimensional (3D) constricted channel represents a challenging topic and has many important applications in bio-medical engineering. In this research, we numerically investigate the physics of a physiological pulsatile flow confined within a 3D channel with an idealized stenosis formed eccentrically on the top wall using the method of large-eddy simulation (LES). The advanced dynamic nonlinear subgrid-scale stress (SGS) model of Wang and Bergstrom [1] was implemented in the current LES approach to properly resolve the unrealistic SGS dissipation effects and numerical instabilities that are intrinsic to the Smagorinsky type dynamic models (DM). The Reynolds numbers tested in the simulation are 1700 and 2000, which are characteristic of human blood flows in large arteries. An in-house 3-D LES code has been modified to conduct our unsteady numerical simulations, and the results obtained have been validated using two different grid arrangements and the experimental results of Ahmed and Giddens [2]. The numerical results have been examined in terms of the resolved mean velocity, turbulence kinetic energy, viscous wall shear stress, resolved and subgrid-scale Reynolds stresses, as well as the local kinetic energy fluxes between the filtered and subgrid scales.

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