Creating monodispersed hydrogel microparticles is advantageous for drug delivery applications. We explore microfluidic flow focusing as a method for generating such particles. Our hydrogel has a unique composition that makes it biodegradable and mechanically strong. We designed and manufactured a polymer microfluidic chip that mixes three viscous precursor solutions and generates a steady stream of microparticles from that solution. We found that microfluidic flow focusing produce particle with a coefficient of variance around 9%; this was a four times improvement over traditional methods.
- Fluids Engineering Division
Microfluidic Formation of Hydrogel Microparticles for Drug Delivery
- Views Icon Views
- Share Icon Share
- Search Site
Betz, A, Zhang, H, Chen, W, & Attinger, D. "Microfluidic Formation of Hydrogel Microparticles for Drug Delivery." Proceedings of the ASME 2010 8th International Conference on Nanochannels, Microchannels, and Minichannels collocated with 3rd Joint US-European Fluids Engineering Summer Meeting. ASME 2010 8th International Conference on Nanochannels, Microchannels, and Minichannels: Parts A and B. Montreal, Quebec, Canada. August 1–5, 2010. pp. 51-55. ASME. https://doi.org/10.1115/FEDSM-ICNMM2010-30717
Download citation file: