Since the capillary electrophoresis was proposed to be run in the chip format, tremendous studies have been performed by covering many different aspects of this technology. One key element is the sample plug generated between the injection and separation process, because it will play a governing role on the final separation performance, i.e., the separation efficiency depends on the initial sample plug and its further dispersion development. In literature, some work has been done previously to generate various sample plugs, or optimize them by means of either channel design or operational control. However, little work has been reported to characterize the sample plug with evaluating parameters. Usually, the well-defined and reproducible sample plug is anticipated for high quality separation. By experience, thin-rectangular sample plugs are normally assumed, but not technically proved yet, to have superior performance in electrophoretic separation. Quantitative study is necessary to be performed to demonstrate the relevant qualitative estimation or analysis. All above stated are the motivation of current work.
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ASME 2010 8th International Conference on Nanochannels, Microchannels, and Minichannels collocated with 3rd Joint US-European Fluids Engineering Summer Meeting
August 1–5, 2010
Montreal, Quebec, Canada
Conference Sponsors:
- Fluids Engineering Division
ISBN:
978-0-7918-5450-1
PROCEEDINGS PAPER
Characterization of Injected Sample Plugs in Microchip Capillary Electrophoresis
Zhanjie Shao,
Zhanjie Shao
University of Waterloo, Waterloo, ON, Canada
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Gerry Schneider,
Gerry Schneider
University of Waterloo, Waterloo, ON, Canada
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Carolyn Ren
Carolyn Ren
University of Waterloo, Waterloo, ON, Canada
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Zhanjie Shao
University of Waterloo, Waterloo, ON, Canada
Gerry Schneider
University of Waterloo, Waterloo, ON, Canada
Carolyn Ren
University of Waterloo, Waterloo, ON, Canada
Paper No:
FEDSM-ICNMM2010-30499, pp. 271-272; 2 pages
Published Online:
March 1, 2011
Citation
Shao, Z, Schneider, G, & Ren, C. "Characterization of Injected Sample Plugs in Microchip Capillary Electrophoresis." Proceedings of the ASME 2010 8th International Conference on Nanochannels, Microchannels, and Minichannels collocated with 3rd Joint US-European Fluids Engineering Summer Meeting. ASME 2010 8th International Conference on Nanochannels, Microchannels, and Minichannels: Parts A and B. Montreal, Quebec, Canada. August 1–5, 2010. pp. 271-272. ASME. https://doi.org/10.1115/FEDSM-ICNMM2010-30499
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