Protein microarrays have been employed to screen tens to thousands of proteins simultaneously for the observation of the biochemical activities in the protein-protein, protein-nucleic acid and small molecule interactions. This technology allows high throughput analysis and holds great potential for basic molecular biology research, disease marker identification, toxicological response profiling and pharmaceutical target screening. However, proteins easily malfunction in harsh environments so that they are hardly preserved before the application because of their complex and fragile structures. On the other hand, identify scarce amount of proteins less than fM range is very important and challenge for disease diagnosis at very early stage. As a result, the procedures for protein micro array formation are very important for preserving protein functionality to ensure useful protein assays, as well as the improvement of the detection sensitivity up to single molecule event but with high dynamic range for disease early detection. Therefore, this paper provides a novel view from the preparation of high efficient protein micro chip toward ultra high sensitive single protein nano array through the technology integration of BioMEMS and Bio-Nanotechnology.
Skip Nav Destination
ASME 2009 7th International Conference on Nanochannels, Microchannels, and Minichannels
June 22–24, 2009
Pohang, South Korea
Conference Sponsors:
- Nanotechnology Institute
ISBN:
978-0-7918-4349-9
PROCEEDINGS PAPER
From High Performance Protein Micro Chip Toward Ultra High Sensitive Single Molecule Nano Array
Fan-Gang Tseng
Fan-Gang Tseng
National Tsing-Hua University, Hsinchu, Taiwan
Search for other works by this author on:
Fan-Gang Tseng
National Tsing-Hua University, Hsinchu, Taiwan
Paper No:
ICNMM2009-82291, pp. 1439-1443; 5 pages
Published Online:
September 21, 2010
Citation
Tseng, F. "From High Performance Protein Micro Chip Toward Ultra High Sensitive Single Molecule Nano Array." Proceedings of the ASME 2009 7th International Conference on Nanochannels, Microchannels, and Minichannels. ASME 2009 7th International Conference on Nanochannels, Microchannels and Minichannels. Pohang, South Korea. June 22–24, 2009. pp. 1439-1443. ASME. https://doi.org/10.1115/ICNMM2009-82291
Download citation file:
3
Views
Related Proceedings Papers
Related Articles
Related Chapters
Component and Printed Circuit Board
Thermal Management of Telecommunication Equipment, Second Edition
Test and Diagnosis Model of Complicated Integrated Circuit with CPU
International Conference on Information Technology and Management Engineering (ITME 2011)
RISP Configuration Overhead Optimization Using an Efficient Configuration Unit
International Conference on Advanced Computer Theory and Engineering (ICACTE 2009)