Vascular structure — a network of convective paths — is a ubiquitous element in multicellular, living systems. The key function of vascular structure in animals and plants is mediation of convective mass transfer over macroscopic distances; this transfer allows an organism to monitor and control the chemical state of its tissues. In our laboratory, we are developing methods to embed and operate microfluidic systems within tissue-like materials in order to capture this function for both biological and non-biological applications. I will present two examples to illustrate our efforts: 1) Capillary beds for the culture of mammalian cells in three-dimensions. In this section, I will discuss the development of methods both to fabricate synthetic capillary beds and to grow them directly out of endothelial cells. I will highlight how simple ideas from continuum mechanics and material science have guided our efforts. 2) Synthetic xylem networks that allow for the transpiration of water at large negative pressures. I will point out the unusual thermodynamic and transport phenomena that are involved in the transpiration process in plants. I will then present our perspectives on the design criteria for systems — synthetic and biological — that mediate this process. Finally, I will describe our experiments with “synthetic trees” in which we have reproduced the main features of transpiration. I will conclude with perspectives on applications and generalizations of both these classes of vascularized materials.
- Nanotechnology Institute
Microvascular Structure and Function in Vitro
- Views Icon Views
- Share Icon Share
- Search Site
Stroock, AD, Choi, NW, Wheeler, TD, Cross, V, Verbridge, S, Fischbach, C, & Bonassar, LJ. "Microvascular Structure and Function in Vitro." Proceedings of the ASME 2009 7th International Conference on Nanochannels, Microchannels, and Minichannels. ASME 2009 7th International Conference on Nanochannels, Microchannels and Minichannels. Pohang, South Korea. June 22–24, 2009. pp. 1195-1202. ASME. https://doi.org/10.1115/ICNMM2009-82124
Download citation file: