Leukocyte rolling and adhesion are complex physiological processes that have received a great deal of attention over the past decade. Significant increases in the knowledge base related to how leukocytes adhere in shear flows have occurred as a result of the development of novel experimental and computational techniques. Micro- and nano-fabrication techniques have enabled the development of novel flow devices for studying leukocyte adhesion in simple and complex geometries. Improvements in computer technology have enabled simulations of complex flow processes to be developed. As a result of these advances in knowledge related to leukocyte adhesion, numerous novel devices have been developed that mimic the leukocyte rolling and adhesion process. Examples of these devices include cell separation and enrichment devices and targeted ultrasound contrast agents. Future advances related to leukocyte rolling and adhesion processes hold great promise for advancing our knowledge of disease processes as well as development of novel therapeutic devices.
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ASME 2008 6th International Conference on Nanochannels, Microchannels, and Minichannels
June 23–25, 2008
Darmstadt, Germany
Conference Sponsors:
- Nanotechnology Institute
ISBN:
0-7918-4834-5
PROCEEDINGS PAPER
Hydrodynamics and Leukocyte Adhesion in Microvessels: State of the Art Available to Purchase
Josa Hanzlik,
Josa Hanzlik
Rochester Institute of Technology, Rochester, NY
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Ellen Cretekos,
Ellen Cretekos
Rochester Institute of Technology, Rochester, NY
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Kathleen A. Lemkin-Kennard
Kathleen A. Lemkin-Kennard
Rochester Institute of Technology, Rochester, NY
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Josa Hanzlik
Rochester Institute of Technology, Rochester, NY
Ellen Cretekos
Rochester Institute of Technology, Rochester, NY
Kathleen A. Lemkin-Kennard
Rochester Institute of Technology, Rochester, NY
Paper No:
ICNMM2008-62067, pp. 1851-1859; 9 pages
Published Online:
June 11, 2009
Citation
Hanzlik, J, Cretekos, E, & Lemkin-Kennard, KA. "Hydrodynamics and Leukocyte Adhesion in Microvessels: State of the Art." Proceedings of the ASME 2008 6th International Conference on Nanochannels, Microchannels, and Minichannels. ASME 2008 6th International Conference on Nanochannels, Microchannels, and Minichannels. Darmstadt, Germany. June 23–25, 2008. pp. 1851-1859. ASME. https://doi.org/10.1115/ICNMM2008-62067
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