In this paper we present a structural and geometrical optimization of a microfluidic gate-controlled magnetic bead system for DNA Sequencing by Synthesis technology. To optimize the efficiency of the technology, we designed, fabricated and tested several structures of the GCMB platform. Different designs of the system were created to study the effects of the pressure, structure, geometry, materials, thickness of intermediate layer between flow and control lines; Toward optimization of the system for a better sensing and to concentrate signal (e.g. heat in Thermosequencing [4–9]) into specific regions for detection in the real system, we recommend an optimized modified gated structure for the microfluidic detection platform and show how this new platform could improve the detection efficiency.

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