Pulsed electromagnetic field (PEMF) treatment is a potentially non-invasive method for tissue engineering. In this paper, a theoretical model is established to simulate the regeneration of articular cartilage for Osteoarthritis by means of pulsed electromagnetic fields (PEMF). The electrical field, flow field, single particle motion and concentration field during the growth of chondrocyte are obtained by solving the theoretical model numerically, which accounts for cell distribution in the culture dish. The induced electric field strength can be numerically obtained by Maxwell’s equation and then the potential distribution by the Poisson equation and Laplace equation. The chondrocytes can be driven to move once the electric field is built up. In the calculation of the flow field, the continuity and momentum equation are applied to obtain the bulk electroosmotic velocity field which will affect the motion of the charged cell due to viscous drag forces. The motion of a single particle can be obtained by the classic Newton’s second law. In addition to a single particle, the concentration distribution of particles which indicates the migration of chondrocytes can be described by the conservation law of mass. Boundary conditions are required to solve these sets of equations numerically. A comparison between model results and actual experimental data for the growth and migration of chondrocytes is performed. The results presented here allow a better understanding of the role PEMF in the treatment of Osteoarthritis.
Skip Nav Destination
ASME 3rd International Conference on Microchannels and Minichannels
June 13–15, 2005
Toronto, Ontario, Canada
Conference Sponsors:
- Nanotechnology Institute
ISBN:
0-7918-4185-5
PROCEEDINGS PAPER
A Microfluidic Model for the Migration of Chondrocyte Under Pulsed Electromagnetic Field Available to Purchase
Ye Tang,
Ye Tang
University of Alberta, Edmonton, AB, Canada
Search for other works by this author on:
Fuzhi Tian,
Fuzhi Tian
University of Alberta, Edmonton, AB, Canada
Search for other works by this author on:
Edmond Lou,
Edmond Lou
University of Alberta, Edmonton, AB, Canada
Search for other works by this author on:
Keith Bagnall,
Keith Bagnall
University of Alberta, Edmonton, AB, Canada
Search for other works by this author on:
John Cinats,
John Cinats
University of Alberta, Edmonton, AB, Canada
Search for other works by this author on:
Nadr Jomha,
Nadr Jomha
University of Alberta, Edmonton, AB, Canada
Search for other works by this author on:
James Raso,
James Raso
University of Alberta, Edmonton, AB, Canada
Search for other works by this author on:
Daniel Y. Kwok
Daniel Y. Kwok
University of Alberta, Edmonton, AB, Canada
Search for other works by this author on:
Ye Tang
University of Alberta, Edmonton, AB, Canada
Fuzhi Tian
University of Alberta, Edmonton, AB, Canada
Edmond Lou
University of Alberta, Edmonton, AB, Canada
Keith Bagnall
University of Alberta, Edmonton, AB, Canada
John Cinats
University of Alberta, Edmonton, AB, Canada
Nadr Jomha
University of Alberta, Edmonton, AB, Canada
James Raso
University of Alberta, Edmonton, AB, Canada
Daniel Y. Kwok
University of Alberta, Edmonton, AB, Canada
Paper No:
ICMM2005-75173, pp. 743-749; 7 pages
Published Online:
November 11, 2008
Citation
Tang, Y, Tian, F, Lou, E, Bagnall, K, Cinats, J, Jomha, N, Raso, J, & Kwok, DY. "A Microfluidic Model for the Migration of Chondrocyte Under Pulsed Electromagnetic Field." Proceedings of the ASME 3rd International Conference on Microchannels and Minichannels. ASME 3rd International Conference on Microchannels and Minichannels, Parts A and B. Toronto, Ontario, Canada. June 13–15, 2005. pp. 743-749. ASME. https://doi.org/10.1115/ICMM2005-75173
Download citation file:
13
Views
Related Proceedings Papers
Related Articles
Parametric Finite Element Analysis of Physical Stimuli Resulting From Mechanical Stimulation of Tissue Engineered Cartilage
J Biomech Eng (June,2009)
Alterations in the Mechanical Properties of the Human Chondrocyte Pericellular Matrix With Osteoarthritis
J Biomech Eng (June,2003)
Mechanical Characterization of Differentiated Human Embryonic Stem Cells
J Biomech Eng (June,2009)
Related Chapters
Effects of Ultrasound Stimulation on Chondrocytes in Three-Dimensional Culture in Relation to the Production of Regenerative Cartilage Tissue
Biomedical Applications of Vibration and Acoustics in Therapy, Bioeffect and Modeling
Chick Embryo Limb Bud Cell Culture for Screening Environmental Contaminants
Environmental Toxicology and Risk Assessment: Modeling and Risk Assessment Sixth Volume
Motion of Charged Bodies in an Electric Field
Dynamics of Particles and Rigid Bodies: A Self-Learning Approach