Fulminant hepatic failure is a clinical syndrome associated with a high mortality rate. Orthotopic liver transplantation is the only clinically proven effective treatment for patients with end-stage liver disease who do not respond to medical management. A major limitation of this treatment modality is the scarcity of donor organs available, resulting in patients dying while waiting for a donor liver. An extracorporeal bioartificial liver (BAL) device containing viable hepatocytes has the potential to provide temporary hepatic support to liver failure patients, serving as a bridge to transplantation while awaiting a suitable donor. In some patients, providing temporary hepatic support may be sufficient to allow adequate regeneration of the host liver, thereby eliminating the need for a liver transplant. Although the BAL device is a promising technology for the treatment of liver failure, there are several technical challenges that must be overcome in order to develop systems with sufficient processing capacity and of manageable size. In this overview, the authors describe the critical issues involved in developing a BAL device. They also discuss their experiences in hepatocyte culture optimization within the context of a microchannel flat-plate BAL device.
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ASME 3rd International Conference on Microchannels and Minichannels
June 13–15, 2005
Toronto, Ontario, Canada
Conference Sponsors:
- Nanotechnology Institute
ISBN:
0-7918-4185-5
PROCEEDINGS PAPER
Engineering a Bioartificial Liver Device (Keynote)
Arno W. Tilles,
Arno W. Tilles
Harvard Medical School, Boston, MA
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Jaesung Park
Jaesung Park
Harvard Medical School, Boston, MA
Search for other works by this author on:
Arno W. Tilles
Harvard Medical School, Boston, MA
Jaesung Park
Harvard Medical School, Boston, MA
Paper No:
ICMM2005-75094, pp. 119-126; 8 pages
Published Online:
November 11, 2008
Citation
Tilles, AW, & Park, J. "Engineering a Bioartificial Liver Device (Keynote)." Proceedings of the ASME 3rd International Conference on Microchannels and Minichannels. ASME 3rd International Conference on Microchannels and Minichannels, Parts A and B. Toronto, Ontario, Canada. June 13–15, 2005. pp. 119-126. ASME. https://doi.org/10.1115/ICMM2005-75094
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