Flow in microchannels is usually slow and the mixing of several fluids is poor if only relying on diffusion. A microchannel mixer with a simple design that is capable of rapid mixing is important for practical applications such as biochemistry analysis. In this study, a general numerical approach to analyze microchannel flow is proposed. The method is based on numerical particle tracking and computer graphics techniques. As a case study, an electro-osmotic driven microchannel mixer is considered with four geometric configurations. The microchannel has a repeated oblique-angled stripe pattern of zeta potential coatings on its floor. The comparison of the particle residence time distributions gives some indication of the mixers’ performances. The efficiency of mixing two flow streams at Pe´clet numbers 2 × 105 and 2 × 104 is then evaluated using the developed procedure. The results indicate that the stripe length ratio is one of the parameters that can be optimized for better mixing. Of the three stripe length ratios evaluated, the configuration with the stripe length ratio 2.0 is found to be the best. In addition, this case study demonstrates that the developed numerical technique is suitable for expeditious parametric optimization of mixer design.

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