The two phase flow of air-water mixture in circular and rectangular channels with hydraulic diameters of 100 μm to 1 mm has been modeled via computational tools. Two phase flow patterns obtained from the computed results have been compared to those of the ones reported in literature and a reasonable agreement has been obtained. After the validation of the computational procedure, keeping the dimensionless numbers relevant to the small hydraulic diameters constant, the size of the channel has been changed to understand the transition to the flow regime in which the “conventional” governing equations fail. Gas and liquid superficial velocities range from 0.083 m/s to 70 m/s and from 0.043 m/s to 5.67 m/s, respectively.

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