Prediction of radionuclides release is a central issue in the performance assessment of nuclear waste repositories. To this aim a model of radionuclides migration through the repository barriers must be set up, accounting for the uncertainties affecting the process. In this context, the present paper presents the application of Monte Carlo simulation to a Markovian modeling framework proposed in the literature; two cases are presented to highlight the value added by the flexibility of the Monte Carlo simulation approach.

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