Gasoline compression ignition (GCI) is a promising way to achieve high thermal efficiency and low emissions while leveraging conventional diesel engine hardware. GCI is a partially premixed combustion concept, which derives its superiority from good volatility and long ignition delay of gasoline-like fuels. The present study investigates the interaction between the piston bowl and the spray plume of a compression ignition engine that operates with a late fuel injection strategy using computational fluid dynamics (CFD) analysis. Simulations were carried out on a single cylinder of a multi-cylinder heavy-duty compression ignition engine. The engine operates at a speed of 1038 rev/min., and a compression ratio of 17. Incylinder turbulence was modelled using RNG k-ε model and the fuel spray break up was modelled using KH-RT model. A reduced chemical kinetic mechanism was used to model combustion chemistry. After validating the combustion and performance characteristics of the baseline piston against experimental results, several new piston bowl designs were generated using CAESES. Full cycle engine simulations for four selected bowl profiles were carried out. The results compare the spray-bowl interaction of the new piston bowl designs with the baseline design. It was found that the lip location and center depth of the bowl profile are the critical design parameters that influence the air utilization and heat transfer losses. The impact of spray-bowl interaction on thermal efficiency of the engine is investigated.