A 2.45 GHz radio frequency (RF) exposure system was designed and used to study the RF effects on the genome-wide gene expression in cultured human cells. In this system, a T-25 culture flask, which contains 10 × 106 cells in a 10ml medium, is placed in a WR 340 waveguide. The waveguide serves as an environmental chamber. The source is a pulsed magnetron for obtaining a high electric field with the specific absorption rate (SAR) at approximately 10 W/kg. In order to ensure the non-thermal effect, the system was designed to maintain a temperature of 37°C. In this research, the heat transfer analysis of the system was conducted using the computational fluid dynamic (CFD) software FLUENT® coupled with the finite element software, High Frequency Structural Simulation (HFSS) by Ansoft. The electric field was first analyzed by using HFSS to calculate the SAR distribution as a heat source input for CFD calculations. The fluid flow and temperature distributions within the flask were then analyzed using FLUENT®. The results were validated experimentally by measuring the temperatures with fluoroptic thermometer probes as well as by examining the level of heat shock gene expression. These results provide useful information for a better understanding and controlling of the operating conditions of the system.
Skip Nav Destination
ASME 2005 Summer Heat Transfer Conference collocated with the ASME 2005 Pacific Rim Technical Conference and Exhibition on Integration and Packaging of MEMS, NEMS, and Electronic Systems
July 17–22, 2005
San Francisco, California, USA
Conference Sponsors:
- Heat Transfer Division and Electronic and Photonic Packaging Division
ISBN:
0-7918-4733-0
PROCEEDINGS PAPER
Heat Transfer Analysis of Human Cell Culture Under RF Exposure Available to Purchase
Muhammad Khalid,
Muhammad Khalid
Purdue University Calumet, Hammond, IN
Search for other works by this author on:
Chenn Zhou,
Chenn Zhou
Purdue University Calumet, Hammond, IN
Search for other works by this author on:
Ashish Bassi,
Ashish Bassi
Purdue University Calumet, Hammond, IN
Search for other works by this author on:
San Ming Wang,
San Ming Wang
Northwestern University, Evanston, IL
Search for other works by this author on:
Howard Gerber,
Howard Gerber
Purdue University Calumet, Hammond, IN
Search for other works by this author on:
Charles Tseng
Charles Tseng
Purdue University Calumet, Hammond, IN
Search for other works by this author on:
Muhammad Khalid
Purdue University Calumet, Hammond, IN
Chenn Zhou
Purdue University Calumet, Hammond, IN
Ashish Bassi
Purdue University Calumet, Hammond, IN
San Ming Wang
Northwestern University, Evanston, IL
Howard Gerber
Purdue University Calumet, Hammond, IN
Charles Tseng
Purdue University Calumet, Hammond, IN
Paper No:
HT2005-72655, pp. 641-649; 9 pages
Published Online:
March 9, 2009
Citation
Khalid, M, Zhou, C, Bassi, A, Wang, SM, Gerber, H, & Tseng, C. "Heat Transfer Analysis of Human Cell Culture Under RF Exposure." Proceedings of the ASME 2005 Summer Heat Transfer Conference collocated with the ASME 2005 Pacific Rim Technical Conference and Exhibition on Integration and Packaging of MEMS, NEMS, and Electronic Systems. Heat Transfer: Volume 3. San Francisco, California, USA. July 17–22, 2005. pp. 641-649. ASME. https://doi.org/10.1115/HT2005-72655
Download citation file:
8
Views
Related Proceedings Papers
Related Articles
Interactions Between Electromagnetic and Thermal Fields in Microwave Heating of Hardened Type I-Cement Paste Using a Rectangular Waveguide (Influence of Frequency and Sample Size)
J. Heat Transfer (August,2009)
Numerical Analysis of Specific Absorption Rate and Heat Transfer in Human Head Subjected to Mobile Phone Radiation: Effects of User Age and Radiated Power
J. Heat Transfer (December,2012)
Experimental Investigation on the Heat Transfer Between a Heated Microcantilever and a Substrate
J. Heat Transfer (October,2008)
Related Chapters
List of Commercial Codes
Introduction to Finite Element, Boundary Element, and Meshless Methods: With Applications to Heat Transfer and Fluid Flow
Conclusion
Introduction to Finite Element, Boundary Element, and Meshless Methods: With Applications to Heat Transfer and Fluid Flow
Experimental Investigation of an Improved Thermal Response Test Equipment for Ground Source Heat Pump Systems
Inaugural US-EU-China Thermophysics Conference-Renewable Energy 2009 (UECTC 2009 Proceedings)