A numerical model is developed to study the electromagnetic and thermal responses of normal and cancerous tissues under microwave hyperthermia. The numerical model is 3-D dimensional with full integration of electromagnetic and thermal phenomena. The model development employs a finite difference time domain (FDTD) method for electromagnetic calculations and an implicit transient node finite element (FEM) method for thermal calculations. The multi-scale microwave-propagation and thermal diffusion phenomena are coupled either directly or indirectly, depending up of the properties of the tissues. The calculated quantities include the absorbed source distribution, heating pattern, and temperature distributions within the tissues consisting of skin, fat, muscle and blood flows. The calculated results are compared with experimental measurements.

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