To further our understanding on the water permeation process through a lipid bilayer membrane in the presence of a commonly used cryoprotective agent (methanol), we performed detailed molecular dynamics simulation (MD) studies. The MD simulations analyzed the influence of methanol (12 mol %) on the structure of a fully hydrated dipalmitoylphosphatidylcholine (DPPC) in the fluid phase and under equilibrium conditions at 323K.
- Heat Transfer Division and Electronic and Photonic Packaging Division
A Molecular Dynamics Simulation Study on the Effect of Methanol on the Structural Characteristics of Lipid Bilayers
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Pinisetty, D, Moldovan, D, & Devireddy, R. "A Molecular Dynamics Simulation Study on the Effect of Methanol on the Structural Characteristics of Lipid Bilayers." Proceedings of the ASME 2005 Summer Heat Transfer Conference collocated with the ASME 2005 Pacific Rim Technical Conference and Exhibition on Integration and Packaging of MEMS, NEMS, and Electronic Systems. Heat Transfer: Volume 1. San Francisco, California, USA. July 17–22, 2005. pp. 811-815. ASME. https://doi.org/10.1115/HT2005-72301
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