Aiming at investigating the effects of crossflow and vortex generator on film cooling characteristics of fan-shaped hole, the film cooling performance was measured experimentally by infrared camera. The blowing ratio is fixed at 0.5 and 1.5. The Reynolds number of the mainstream based on the hole diameter remains at 7000 and the inlet Reynolds number of crossflow is 40000. The experimental results show that the film cooling performance becomes better when the blowing ratio increases from 0.5 to 1.5 for each model, and the film cooling performance becomes worse under the influence of crossflow. When the blowing ratio is 1.5, the area-averaged film cooling effectiveness of the fan-shaped hole model with vortex generator decreases by 16.6% because of the influence of crossflow. The combined model always performs better compared with the model without vortex generator under all working conditions. When the blowing ratio becomes 1.5, under the influence of crossflow, the area-averaged film cooling effectiveness of the combined model could increase by 14.8%, compared with the model without vortex generator. To further improve the film cooling performance, the global optimization algorithm based on the Kriging method and the CFD technology are coupled to optimize the combined model under crossflow condition at the high blowing ratio, and the optimized design is verified by experiments. The experimental results show that the area-averaged film cooling effectiveness of the optimized design increases by 17.8% compared with the reference model.