This paper presents a general methodology for the development and simulation of a human lung between scales 0–16. The methodology is based on the simulation of only one of the two possible branches at each bronchiole. The operation of the truncated branches is included by means of a user-defined function. This function prescribes the velocity profile calculated for the active branches in the truncated ones in order to make the hydraulic losses equal between them. This procedure was tested between 0 and 7th generation by imposing the time profile of a real forced spirometry test in the trachea as boundary condition. The test showed a very good agreement between the numerical predictions and the spirometry data.

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